PAK1 (phospho T423) Peptide
产品名称： PAK1 (phospho T423) Peptide
英文名称： PAK1 (phospho T423) Peptide
产品编号： P1549
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of PAK1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T423 of human PAK1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.
DerMardirossian C, Schnelzer A, Bokoch GM.Mol Cell. 2004 Jul 2;15(1):117-27.
- 2.
- The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.
Li W, Guan KL.J Biol Chem. 2004 Jul 30;279(31):32824-31. Epub 2004 May 28.
- 3.
- Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.
Weber DS, Taniyama Y, Rocic P, Seshiah PN, Dechert MA, Gerthoffer WT, Griendling KK.Circ Res. 2004 May 14;94(9):1219-26. Epub 2004 Apr 1.
- Entrez GeneID:
- 5058
- Protein Accession#:
- NP_002567;Q13153
- Gene Name:
- PAK1
- Gene Alias:
- MGC130000,MGC130001,PAKalpha
- Gene Description:
- p21 protein (Cdc42/Rac)-activated kinase 1
- Omim ID:
- 602590
- Gene Ontology:
- Hyperlink
- Gene Summary:
- PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- STE20 homolog, yeast,p21-activated kinase 1,p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast),p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
- Gene Pathway
- Axon guidance
- Chemokine signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- MAPK signaling pathway
- Natural killer cell mediated cytotoxicity
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway