产品概述：Recombinant protein of human v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600D mutant, expressed in human cells

蛋白长度：A DNA sequence from GoldORF clone, [GHM0158V], encoding the V600D mutant form of human BRAF

表达系统：HEK293

种属：Human

标签类型：C-Myc/DDK

分子量：84 kDa

通用名：BRAF

总结：This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

别名：B-raf; B-RAF1; BRAF1; NS7; RAFB1