FITC标记的转录因子COUP1抗体
产品名称： FITC标记的转录因子COUP1抗体
英文名称： Anti-COUP-TF1/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-COUP-TF1/FITC Conjugated antibody
FITC标记的转录因子COUP1抗体
| 英文名称 | Anti-COUP-TF1/FITC |
| 中文名称 | FITC标记的转录因子COUP1抗体 |
| 别 名 | Chicken ovalbumin upstream promoter 1; chicken ovalbumin upstream promoter; COT1_HUMAN; COUP transcription factor 1; COUP transcription factor I; COUP-TF I; COUP TF1; EAR-3; EAR3; ERBAL3; NR2F1; Nuclear receptor subfamily 2 group F member 1; SVP44; TCFCOUP1; TFCOUP1; Transcription factor COUP 1; V ERBA related protein EAR 3; V-erbA-related protein 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞粘附分子 细胞外基质 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COUP-TF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: COUP transcription factors have been cloned in several species and identified as orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TFI (also designated COUP or EAR-3) and ARP-1 (also designated COUP-TFII) exhibit highly regulated and overlapping expression in most tissues. COUP-TFs are highly expressed in the developing and central nervous system, suggesting that these factors may be important in neural development and differentiation. COUP-TFs can compete for binding to response elements which are common to other members of this family, including RAR, RXR, PPAR, HNF-4, VDR and TR. They have been shown to act as negative regulators as well as initiators of transcription. Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. Subunit: Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2. Subcellular Location: Nucleus. Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 7025 Human Entrez Gene: 13865 Mouse Entrez Gene: 81808 Rat Omim: 132890 Human SwissProt: P10589 Human SwissProt: Q60632 Mouse Unigene: 519445 Human Unigene: 439653 Mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
COUP转录因子已经在几种物种中被克隆，并且被鉴定为类固醇/甲状腺受体超家族的孤儿成员。COUP-TFI(也称为COUP或EAR-3)和ARP-1(也称为COUP-TFII)在大多数组织中显示高度调节和重叠的表达。COUP-TF在发育期和中枢神经系统中高度表达，提示这些因素可能在神经发育和分化中起重要作用。COUP-TF可以竞争与该家族其他成员共有的反应元件结合，包括RAR、RXR、PPAR、HNF-4、VDR和TR。它们被证明是负调控因子和转录启动子。