DDX26/DICE1,癌基因删去蛋白DICE1抗体

产品编号HZ-14222R
英文名称DDX26/DICE1
中文名称癌基因删去蛋白DICE1抗体
别 名DBI 1; DBI-1; DBI1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26; Deleted in cancer 1; DICE1; DKFZp434B105; HDB; Int6; INT6_HUMAN; Integrator complex subunit 6; INTS 6; INTS6; Notchl2; OTTHUMP00000018439; OTTHUMP00000215034; OTTHUMP00000215036; Protein DDX26; Protein deleted in cancer 1; RNA helicase HDB.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 转运蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Horse, Rabbit,
DDX26/DICE1,癌基因删去蛋白DICE1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DDX26/DICE1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DDX26/DICE1,癌基因删去蛋白DICE1抗体PubMedPubMed
产品介绍background:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Similarity:
Belongs to the Integrator subunit 6 family.
Contains 1 VWFA domain.

Gene ID:
26512

DDX26/DICE1,癌基因删去蛋白DICE1抗体Database links:
Entrez Gene: 26512 Human
Omim: 604331 Human
SwissProt: Q9UL03 Human
Unigene: 439440 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.