Aurora A Kinase (Human) Assay/Inhibitor Screening Kit
产品名称: Aurora A Kinase (Human) Assay/Inhibitor Screening Kit
英文名称: Aurora A Kinase (Human) Assay/Inhibitor Screening Kit
产品编号: KA0067
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Aurora A Kinase (Human) Assay/Inhibitor Screening Kit is a single-site, non-quantitative immunoassay for Aurora-A activity. Plates are pre-coated with a substrate corresponding to recombinant Lats2, which contains serine83 residues that can be phosphorylated by Aurora-A. The detector antibody specifically detects only the phosphorylated form of serine83 residue on Lats2.
- Reactivity:
- Human
- Storage Instruction:
- Store the kit at 4°C.
- Quality Control Testing:
- Dose dependent curve
Dose dependent curve of recombinant Aurora-A enzyme reaction.
- Protocol:
- Protocol Download
- Regulation Status:
- For research use only (RUO)
- Publication Reference
- 1.
- Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases.
Pan W, Liu H, Xu YJ, Chen X, Kim KH, Milligan DL, Columbus J, Hadari YR, Kussie P, Wong WC, Labelle M.Bioorg Med Chem Lett. 2005 Dec 15;15(24):5474-7. Epub 2005 Sep 28.
- Application Image
- Functional Study
- Entrez GeneID:
- 6790
- Gene Name:
- AURKA
- Gene Alias:
- AIK,ARK1,AURA,AURORA2,BTAK,MGC34538,STK15,STK6,STK7
- Gene Description:
- aurora kinase A
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
- Other Designations:
- IPL1-related kinase,OTTHUMP00000031340,OTTHUMP00000031342,OTTHUMP00000031343,OTTHUMP00000031344,OTTHUMP00000031345,OTTHUMP00000166071,aurora-A,aurora-related kinase 1,aurora/IPL1-like kinase,breast-tumor-amplified kinase,serine/threonine kinase 15,serine/
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