FITC标记的白介素18抗体
产品名称： FITC标记的白介素18抗体
英文名称： Anti-IL-18/FITC
产品编号： HZ-4988R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-IL-18/FITC Conjugated antibody
FITC标记的白介素18抗体
| 英文名称 | Anti-IL-18/FITC |
| 中文名称 | FITC标记的白介素18抗体 |
| 别 名 | IGIF; interferon gamma-inducing factor IGIF; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; Iboctadekin; IFN gamma inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL1 gamma; IL18 protein; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin 18; Interleukin18; MGC12320; IL18_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 免疫学 细胞因子 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-18/IGIF |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions. Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Subcellular Location: Secreted. Similarity: Belongs to the IL-1 family. Database links: Entrez Gene: 3606 Human Entrez Gene: 16173 Mouse Omim: 600953 Human SwissProt: Q14116 Human SwissProt: P70380 Mouse Unigene: 83077 Human Unigene: 1410 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IL18（IFN-γ诱导因子，IGIF）是一种增强脾细胞自然杀伤（NK）活性的新型促炎细胞因子。该细胞因子可诱导T细胞产生IFN-γ。这种细胞因子产生的组合已被证明能够抑制IL-4依赖IgE和IgG1的生产，提高生产的B细胞抗体。IL18结合蛋白（IL18BP）可与该细胞因子特异性相互作用，从而负调控其生物学活性。
IL18还具有其他生物学特性，如刺激Fas配体表达，以及诱导CC和CXC趋化因子。IL18增加了HIV的产生。IL18与IL1家族有关。IL18受体链之一是IL1受体相关蛋白，IL 1R家族的成员。像IL1、IL18首先被合成为一个群龙无首的前体需要1转换酶（ICE）裂解成活性分子。IL18可能在炎症反应中的组织损伤中起作用。