Neurexin 1 beta,轴突蛋白1β/Neurexin 1β抗体

产品编号HZ-11466R
英文名称Neurexin 1 beta
中文名称轴突蛋白1β/Neurexin 1β抗体
别 名Neurexin I beta; Neurexin 1; Neurexin 1 beta; Neurexin I beta; NRXN1; NRX1B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞粘附分子 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
Neurexin 1 beta,轴突蛋白1β/Neurexin 1β抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Neurexin 1 beta (281-330aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Neurexin 1 beta,轴突蛋白1β/Neurexin 1β抗体PubMedPubMed
产品介绍background:
Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.

Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis

Subunit:
The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2

Subcellular Location:
Membrane; Single pass type I membrane protein

Post-translational modifications:
Highly O-glycosylated and minor N-glycosylated

Similarity:
Belongs to the neurexin family.
Contains 1 laminin G-like domain.

Database links:
UniProtKB/Swiss-Prot: P58400.2

Neurexin 1 beta,轴突蛋白1β/Neurexin 1β抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片	Western blot analysis of extracts from U20s using Neurexin1 beta antibody. (Primary dilution:1:300)