Decorin,核心蛋白聚糖抗体

产品编号HZ-1695R
英文名称Decorin
中文名称 核心蛋白聚糖抗体
别 名Decorin; Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG-S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B; PGS2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
Decorin,核心蛋白聚糖抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DCN
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Decorin,核心蛋白聚糖抗体PubMedPubMed
产品介绍background:
Decorin is a member of the small, leucine rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF beta. It is believed that decorin also plays a role in the cell cycle of chondrocytes. Also known as: Decorin; Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B.

Function:
May affect the rate of fibrils formation.

Subunit:
Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Post-translational modifications:
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

DISEASE:
Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance.

Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Contains 12 LRR (leucine-rich) repeats.

Gene ID:
1634

Decorin,核心蛋白聚糖抗体Database links:
Entrez Gene: 1634 Human
Entrez Gene: 13179 Mouse
Entrez Gene: 29139 Rat
Omim: 125255 Human
SwissProt: P07585 Human
SwissProt: P28654 Mouse
SwissProt: Q01129 Rat
Unigene: 728830 Human
Unigene: 56769 Mouse
Unigene: 106103 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

核心蛋白聚糖(decorin)属高分子蛋白多糖类，为蛋白聚糖(PG)的一种,是转化生长因子β(TGFβ)的拮抗剂。Decorin在调节细胞粘附、迁移、增殖、胶原纤维形成活性调节及对TGF-β的负反馈调节中起到一定的作用。