COLEC12,凝集胎盘蛋白1抗体

产品编号HZ-10736R
英文名称COLEC12
中文名称凝集胎盘蛋白1抗体
别 名Collectin placenta protein 1; Collectin placenta 1; Collectin-12; hCL-P1; CL-P1; Nurse cell scavenger receptor; Scavenger receptor with C-type lectin; Scavenger receptor class A member 4; COLEC12; CLP1; NSR2; SCARA4; SRCL. COL12_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 染色质和核信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
COLEC12,凝集胎盘蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human COLEC12
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
COLEC12,凝集胎盘蛋白1抗体PubMedPubMed
产品介绍background:
Colec12 is a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. Colec12 is a scavenger receptor that displays several functions associated with host defense. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast and mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.

Function:
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.

Subunit:
The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide.

Subcellular Location:
Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface.

Tissue Specificity:
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.

Similarity:
Contains 1 C-type lectin domain.
Contains 3 collagen-like domains.

Gene ID:
81035

COLEC12,凝集胎盘蛋白1抗体Database links:
Entrez Gene: 421061 Chicken
Entrez Gene: 504741 Cow
Entrez Gene: 81035 Human
Entrez Gene: 140792 Mouse
Entrez Gene: 361289 Rat
Omim: 607621 Human
SwissProt: Q2LK54 Chicken
SwissProt: A6QP79 Cow
SwissProt: Q5KU26 Human
SwissProt: Q8K4Q8 Mouse
SwissProt: Q4V885 Rat
Unigene: 33741 Chicken
Unigene: 4492 Cow
Unigene: 464422 Human
Unigene: 218571 Mouse
Unigene: 31273 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.