Caspase 4+Caspase 11,半胱胺酸蛋白酶4/11抗体

产品编号HZ-6858R
英文名称Caspase 4+Caspase 11
中文名称半胱胺酸蛋白酶4/11抗体
别 名CASP11; CASP11; Casp4; Caspase 11; Caspase11; Caspase-11; Caspase 4; Caspase4; Caspase-4; Caspase 4 apoptosis related cysteine peptidase; CASPL; CASPL; Ich3; ICH3 protease; ICH3 protease.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
Caspase 4+Caspase 11,半胱胺酸蛋白酶4/11抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse Caspase-4 subunit p20
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Caspase 4+Caspase 11,半胱胺酸蛋白酶4/11抗体PubMedPubMed
产品介绍background:
Caspase 11 (also known as ICH3) gene encodes two protein products of 38 and 43 kDa that belong to the Ced3/ICE family of cysteine proteases. Caspase 11 is an “upstream” caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits. Monoclonal antibodies reacting specifically with caspase 11 are useful tools for the study of the protease network, involved in development and regulation, governing the life and death of cells and tissues.

Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses.

Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit.

Tissue Specificity:
Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain.

Post-translational modifications:
The two subunits are derived from the precursor sequence by a autocatalytic mechanism.

Similarity:
Belongs to the peptidase C14A family.
Contains 1 CARD domain.

Caspase 4+Caspase 11,半胱胺酸蛋白酶4/11抗体Gene ID:
12363

Database links:
Entrez Gene: 837 Human
Entrez Gene: 12363 Mouse
Omim: 602664 Human
SwissProt: P49662 Human
SwissProt: P70343 Mouse
Unigene: 138378 Human
Unigene: 1569 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.