FITC标记的凝血因子11轻链抗体
产品名称： FITC标记的凝血因子11轻链抗体
英文名称： Anti-Factor XI light chain/FITC
产品编号： HZ-9502R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Factor XI light chain/FITC Conjugated antibody
FITC标记的凝血因子11轻链抗体
| 产品编号 | bs-9502R-FITC |
| 英文名称 | Anti-Factor XI light chain/FITC |
| 中文名称 | FITC标记的凝血因子11轻链抗体 |
| 别 名 | Coagulation factor XI; Coagulation factor XIa light chain; F11; FA11_HUMAN; FXI; MGC141891; Plasma thromboplastin antecedent; PTA; Factor XI. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41/69kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Coagulation factor XIa light chain |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]. Function: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Subunit: Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond. Subcellular Location: Secreted. Tissue Specificity: Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. Post-translational modifications: Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. DISEASE: Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 2160 Human Entrez Gene: 290757 Rat Omim: 264900 Human SwissProt: P03951 Human Unigene: 1430 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码凝血因子XI的凝血级联。这种蛋白质存在于作为酶原的血浆中，这是一种独特的血浆凝固酶，因为它存在由由二硫键连接的两个相同的多肽链组成的同型二聚体。在激活血浆因子XI时，内肽键通过因子XIIa（或XII）裂解在两个链中的每一个，导致活化因子XI，由两个重链和两个轻链组成的丝氨酸蛋白酶由二硫键保持在一起。这种活化的血浆因子XI触发凝血因子IX的凝血途径的中间阶段。在该因子中的缺陷导致Rosenthal综合征，凝血异常。[ RefSeq，JUL 2008 ]提供。