PHB polyclonal antibody
产品名称： PHB polyclonal antibody
英文名称： PHB polyclonal antibody
产品编号： PAB2548
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PHB.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to amino acids 189-219 at C-terminus of human PHB.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis.
Gregory-Bass RC, Olatinwo M, Xu W, Matthews R, Stiles JK, Thomas K, Liu D, Tsang B, Thompson WE.Int J Cancer. 2008 May 1;122(9):1923-30.
- 2.
- The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.
Ross JA, Nagy ZS, Kirken RA.J Biol Chem. 2008 Feb 22;283(8):4699-713. Epub 2007 Dec 17.
- 3.
- Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism.
White JJ, Ledbetter DH, Eddy RL Jr, Shows TB, Stewart DA, Nuell MJ, Friedman V, Wood CM, Owens GA, McClung JK, et al..Genomics. 1991 Sep;11(1):228-30.
- Entrez GeneID:
- 5245
- Protein Accession#:
- NP_002625;P35232
- Gene Name:
- PHB
- Gene Alias:
- PHB1
- Gene Description:
- prohibitin
- Omim ID:
- 176705
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq
- Other Designations:
- -