FITC标记的G蛋白结合蛋白2抗体
产品名称： FITC标记的G蛋白结合蛋白2抗体
英文名称： Anti-GBP2/FITC
产品编号： HZ-11288R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GBP2/FITC Conjugated antibody
FITC标记的G蛋白结合蛋白2抗体
| 产品编号 | bs-11288R-FITC |
| 英文名称 | Anti-GBP2/FITC |
| 中文名称 | FITC标记的G蛋白结合蛋白2抗体 |
| 别 名 | GBP 2; GBP2; GBP-2; GTP binding protein 2; Guanine nucleotide binding protein 2; Guanylate binding protein 2 interferon inducible; HuGBP 2; HuGBP2; GBP2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 信号转导 结合蛋白 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GBP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Guanylate-binding proteins, GBP1 and GBP2 are GTP-binding proteins with a high-turnover GTPase activity and an antiviral effect (1-4). GBP1 mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus and plays a role in the IFN-mediated antiviral response against these viruses (4). GBP1 and GBP2 belong to a group of large GTP-binding proteins with a high concentration-dependent GTPase activity that have the common ability to undergo oligomerization (1). GBP1 and GBP2 are bone marrow-derived GTPases encoded by interferon-activated genes and are inducible following IFN treatment (2,3). Specifically, GBP1 is expressed in cultured mammary epithelial tumor cell lines after treatment with IFN-gamma and LPS (5). Function: Guanylate-binding proteins (GBPs) are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). GBP2 is a GTPase that converts GTP to GDP and GMP. Subunit: Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. Subcellular Location: Cytoplasm. Nucleus. Golgi apparatus membrane; Lipid-anchor. Similarity: Belongs to the GBP family. Database links: Entrez Gene: 2634 Human Entrez Gene: 14469 Mouse Entrez Gene: 171164 Rat Omim: 600412 Human SwissProt: P32456 Human SwissProt: Q9Z0E6 Mouse SwissProt: Q63663 Rat Unigene: 386567 Human Unigene: 24038 Mouse Unigene: 25736 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
鸟苷酸结合蛋白，gbp1和gbp2是GTP结合蛋白，具有高的周转GTPASE活性和抗病毒作用（1-4）。GBP1介导了对水疱性口炎病毒和脑心肌炎病毒的抗病毒作用，并在干扰素介导的抗病毒反应中发挥作用。GBP1和GBP2属于一组具有高浓度依赖性GTP酶活性的大GTP结合蛋白，具有共同的寡聚化能力（1）。GBP1和GBP2是由干扰素激活基因编码的骨髓源性GTP酶，在IFN处理（2,3）后可诱导。具体而言，在用IFN-γ和LPS（5）治疗后，在培养的乳腺上皮肿瘤细胞系中表达gbp1。