FITC标记的JWA蛋白抗体
产品名称： FITC标记的JWA蛋白抗体
英文名称： Anti-JWA/FITC
产品编号： HZ-9706R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-JWA/FITC Conjugated antibody
FITC标记的JWA蛋白抗体
| 产品编号 | bs-9706R-FITC |
| 英文名称 | Anti-JWA/FITC |
| 中文名称 | FITC标记的JWA蛋白抗体 |
| 别 名 | Addicsin; ADP ribosylation like factor 6 interacting protein 5; Aip 5; Aip5; ARL 6 interacting protein 5; ARL6IP5 antibody Cytoskeleton related vitamin A responsive protein; Dermal papilla derived protein 11; DERP 11; DERP11; Glutamate transporter EEAC 1 associated protein; Glutamate transporter EEAC1 associated protein; GTRAP3 18; Hp 22; Hp22; HSPC 127; HSPC127; JM 5; JM5; JMX; PRA 1 domain family 3; PRA 2; PRA1 domain family 3; PRA2; PRAF 3; PRAF3; Prenylated Rab acceptor protein 2; Protein JWa; Putative MAPK activating protein PM27; PRAF3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞周期蛋白 转录调节因子 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JWA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals. Function: Regulates intracellular concentrations of taurine andglutamate. Negatively modulates SLC1A1/EAAC1 glutamate transportactivity by decreasing its affinity for glutamate. May be involvedin membrane traffic (By similarity). Subunit: Forms multimers. Binds to prenylated RAB1A and RAB3A, tothe neuronal glutamate transporter SLC1A1/EAAC1, and to theADP-ribosylation like factor ARL6, a member of the Ras superfamily.Does not bind to VAMP2 (By similarity). Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Associated with microtubules. Similarity: Belongs to the PRA1 family. Database links: Entrez Gene: 10550 Human Omim: 605709 Human SwissProt: O75915 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
JWA是一种四跨膜环境应答蛋白，它与人类免疫缺陷病毒（HIV）的主要共受体CC趋化因子受体5（CCR5）结合。JWA参与K562细胞的环境应激反应途径，K562细胞来源于慢性粒细胞白血病患者的红白血病细胞系。K562细胞对环境的应激，如热休克、比理想细胞体温高的细胞来源，以及氧化应激、氧自由基的产生、调节和增加JWA的表达。这种对环境应激的反应表明JWA对热休克蛋白70（HSP70）的相似性，热应激蛋白（HSP70）由热应激和有毒化学品上调。