FITC标记的富含丝氨酸/精氨酸重复结构蛋白抗体
产品名称： FITC标记的富含丝氨酸/精氨酸重复结构蛋白抗体
英文名称： Anti-FUSIP1/FITC
产品编号： HZ-13229R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FUSIP1/FITC Conjugated antibody
FITC标记的富含丝氨酸/精氨酸重复结构蛋白抗体
| 英文名称 | Anti-FUSIP1/FITC |
| 中文名称 | FITC标记的富含丝氨酸/精氨酸重复结构蛋白抗体 |
| 别 名 | 40 kDa SR repressor protein; 40 kDa SR-repressor protein; Anti TLS associated protein with SR repeats; arginine/serine-rich 13A; FUS interacting protein serine arginine rich 1; FUS interacting protein serine arginine rich 2; FUS interacting serine arginine rich protein 1; FUS-interacting serine-arginine-rich protein 1; FUSIP1; FUSIP2; NSSR; OTTHUMP00000015774; Serine arginine repressor protein 40 kDa; Serine/arginine-rich splicing factor 10; SFRS13; SFRS13A; Splicing factor; Splicing factor arginine serine rich 13; Splicing factor SRp38; SRp38; SRp40; SRrp40; SRS10_HUMAN; Srsf10; TASR; TASR1; TASR2; TLS associated protein TASR1; TLS associated protein TASR2; TLS associated protein with Ser Arg repeats; TLS associated protein with SR repeats; TLS associated serine arginine protein 1; TLS associated serine arginine protein 2; TLS associated serine arginine protein; TLS associated SR protein; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞周期蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FUSIP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing. Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. Subunit: The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus. Subcellular Location: Nucleus speckle. Cytoplasm. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. Isoform 3 is phosphorylated on Ser-168. Similarity: Belongs to the splicing factor SR family. Contains 1 RRM (RNA recognition motif) domain. Database links: Entrez Gene: 782389 Cow Entrez Gene: 10772 Human Entrez Gene: 14105 Mouse Entrez Gene: 362630 Rat Omim: 605221 Human SwissProt: O75494 Human SwissProt: Q9R0U0 Mouse Unigene: 3530 Human Unigene: 652334 Human Unigene: 10229 Mouse Unigene: 472035 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FUSSI1是剪接因子丝氨酸/精氨酸（SR）家族的成员。SR家族的成员都包含一个或多个RNA识别基序（RRM）和富含Sr的结构域。SR因子不仅对本构剪接是必不可少的，而且通过影响选择性剪接位点的选择以浓度依赖的方式调节剪接。FUSIP1在肾脏、肝脏、心脏等多种组织中低表达，主要定位于细胞质和核散斑。FUSIP1以其去磷酸化的形式（发生在细胞周期的M期），作为前mRNA剪接的强有力的一般性抑制剂发挥作用，并可与U1 SnRNP 70相互作用。在磷酸化形式中，FUPSI1与TRA-2γ相互作用，共同作用于剪接的调控。四种异构体存在于FUPSI1中。在神经元中，FUPSI1亚型可能对正剪接或负向调节选择性剪接起作用。