FITC标记的心血管发育中胚层相关蛋白1抗体
产品名称： FITC标记的心血管发育中胚层相关蛋白1抗体
英文名称： Anti-MESP1/FITC
产品编号： HZ-9471R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MESP1/FITC Conjugated antibody
FITC标记的心血管发育中胚层相关蛋白1抗体
| 产品编号 | bs-9471R-FITC |
| 英文名称 | Anti-MESP1/FITC |
| 中文名称 | FITC标记的心血管发育中胚层相关蛋白1抗体 |
| 别 名 | bHLHc5; Class C basic helix-loop-helix protein 5; Mesoderm posterior 1; Mesoderm posterior 1 homolog; Mesoderm posterior protein 1; MESP 1; Mesp1; MESP1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MESP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MESP1, also known as bHLHc5, is a 268 amino acid protein that contains one basic helix-loop-helix (bHLH) domain, a motif that mediates protein dimerization and can bind to the E-box sequence of DNA. Localized to the nucleus, MESP1 functions as a transcription factor that, via its bHLH domain, participates in the epithelialization and the development of the cardiac and somitic mesoderm. MESP1 is highly expressed during gastrulation and somitogenesis and is necessary for the formation of single heart tubes during cardiac maturation. Early detection of MESP1 may be an indicator of the formation of cardiac precursor cells in developing embryos. Additionally, MESP1 plays a role in the rostrocaudal patterning of the somites, an event that influences select Notch signaling pathways. Function: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways. Subcellular Location: Nucleus. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 55897 Human Omim: 608689 Human SwissProt: Q9BRJ9 Human Unigene: 447531 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MESP1，也称为BHLHC5，是包含一个基本螺旋-环-螺旋（BHLH）结构域的268氨基酸蛋白，其介导蛋白质二聚化并与DNA的E-box序列结合。定位于细胞核，MESP1作为转录因子，通过其BHLH结构域参与心肌和体节中胚层的上皮化和发育。MEPS1在原肠胚形成和体细胞生成过程中高度表达，是心脏成熟过程中单个心脏管形成所必需的。早期发现MESP1可能是发育中胚胎心脏前体细胞形成的一个指标。此外，MESP1在体节的ROSTROCUDA图案化中起作用，这是影响选择Notch信号通路的事件。