FITC标记的磷酸肌醇磷酸酶蛋白INPP5G抗体
产品名称： FITC标记的磷酸肌醇磷酸酶蛋白INPP5G抗体
英文名称： Anti-Synaptojanin/FITC
产品编号： HZ-11376R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200 not yet tested in other applications
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Rabbit Anti-Synaptojanin/FITC Conjugated antibody
FITC标记的磷酸肌醇磷酸酶蛋白INPP5G抗体
| 产品编号 | bs-11376R-FITC |
| 英文名称 | Anti-Synaptojanin/FITC |
| 中文名称 | FITC标记的磷酸肌醇磷酸酶蛋白INPP5G抗体 |
| 别 名 | 5-trisphosphate 5-phosphatase 1; Inositol 5' phosphatase; INPP 5G; INPP5G; KIAA0910; Polyphosphoinositide phosphatase; Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1; Synaptic inositol 145 trisphosphate 5 phosphatase 1; Synaptic inositol-1 antibody Synaptic inositol-145-trisphosphate 5-phosphatase 1; Synaptojanin 1; Synaptojanin 1 polyphosphoinositide phosphatase; Synaptojanin-1; Synaptojanin1; Synj 1; Synj1; SYNJ1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 173kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptojanin/INPP5G |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Synaptojanins are characterized by an N-terminal SAC1-like sequence, a central 5-phosphate domain, and a unique C-terminal sequence and have been shown to use phosphatidylinositol 4,5-bisphosphate as a substrate. Synaptojanins exist as two isoforms, synaptojanin 1 and 2, which differ in the C-terminal domain, and each isoform has multiple variants produced by alternative splicing. Synaptojanin 1 is expressed as two major forms: the shorter is found in brain while the longer is expressed in peripheral tissues. Eight splice variants of synaptojanin 2 have been detected, including a brain specific isoform. Synaptojanins are thought to participate in the endocytosis of synaptic vesicles and the regulation of the actin cytoskeleton. Function: Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis. Subunit: Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Binds AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Subcellular Location: Cytoplasm. Tissue Specificity: Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals. Similarity: Belongs to the synaptojanin family. In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SAC domain. Database links: Entrez Gene: 104015 Mouse Entrez Gene: 85238 Rat SwissProt: Q8CHC4 Mouse SwissProt: Q62910 Rat Unigene: 187079 Mouse Unigene: 379876 Mouse Unigene: 22685 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肌醇多磷酸5-磷酸酶选择性地从磷酸化磷脂酰肌醇的5位除去磷酸，其响应胞外信号产生第二信使。突触素的特征在于N-端SAC1样序列，中心5-磷酸结构域，和独特的C-末端序列，并已证明使用磷脂酰肌醇4,5-二磷酸作为底物。突触蛋白作为两种异构体存在，突触蛋白1和2，它们在C-末端结构域上不同，并且每个亚型具有多个可变剪接产生的变异体。突触素1主要表达在脑组织中，在脑组织中表达较短，而在外周组织中表达时间较长。已检测到8个突触突触素的剪接变异体，包括脑特异性的异构体。突触蛋白被认为参与突触囊泡的内吞作用和肌动蛋白细胞骨架的调节。