MRXJ/Jarid1C,组蛋白去甲基化Jarid1C抗体

产品编号HZ-8178R
英文名称MRXJ/Jarid1C
中文名称组蛋白去甲基化Jarid1C抗体
别 名SmcX protein; Xe169 protein; DXS1272E; Histone demethylase JARID1C; JmjC domain containing protein SMCX; Jumonji AT rich interactive domain 1C; Jumonji/ARID domain-containing protein 1C; KDM5C; KDM5C_HUMAN; Lysine (K) specific demethylase 5C; Lysine-specific demethylase 5C; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; rbp2 like protein; Selected cDNA on X; Smcx homolog X chromosome; SmcX protein; Smcy homolog X linked; XE169; Xe169 protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 染色质和核信号 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
MRXJ/Jarid1C,组蛋白去甲基化Jarid1C抗体产品应用WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量176kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human KDM5C
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MRXJ/Jarid1C,组蛋白去甲基化Jarid1C抗体PubMedPubMed
产品介绍background:
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Function:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.

Subunit:
Part of two distinct complexes, one containing E2F6, and the other containing REST.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.

MRXJ/Jarid1C,组蛋白去甲基化Jarid1C抗体Similarity:
Belongs to the JARID1 histone demethylase family.
Contains 1 ARID domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 2 PHD-type zinc fingers.

Gene ID:
8242

Database links:
Entrez Gene: 8242 Human
Entrez Gene: 100037295 Pig
Omim: 314690 Human
SwissProt: P41229 Human
Unigene: 631768 Human

MRXJ/Jarid1C,组蛋白去甲基化Jarid1C抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.