FOLH1B,细胞生长抑制蛋白26/前列腺特异性膜抗原样蛋白抗体

产品编号HZ-6535R
英文名称FOLH1B
中文名称细胞生长抑制蛋白26/前列腺特异性膜抗原样蛋白抗体
别 名PSMAL; Cell growth inhibiting gene 26 protein; Folate hydrolase 1B; Folate hydrolase 2; Folate hydrolase pseudogene; FOLH2; FOLHP; GCP3; GCPIII; glutamate carboxypeptidase III; N acetylated alpha linked acidic dipeptidase; NAALADase; Prostate specific membrane antigen like protein; PSM; PSMA like; Putative folate hydrolase 1B; Putative N acetylated alpha linked acidic dipeptidase; FOH1B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 信号转导 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
FOLH1B,细胞生长抑制蛋白26/前列腺特异性膜抗原样蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FOLH1B (181-225aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FOLH1B,细胞生长抑制蛋白26/前列腺特异性膜抗原样蛋白抗体PubMedPubMed
产品介绍background:
Prostate cancer is the most frequently diagnosed cancer and the early detection of prostate cancer dramatically and efficiently reduces the observed mortality rate. Several proteins have been identified as specific markers of prostate cancer, and they may be useful as diagnostic indicators. PSA, prostate specific antigen, is the classical indicator for transformed prostate tissue; however, in addition to being upregulated in prostate cancer, PSA is also upregulated in non-malignant conditions, such as benign prostatic hyperplasia prostate. Conversely, STEAP (six-transmembrane epithelial antigen of the prostate), prostate carcinoma tumor antigen (PCTA-1) and prostate-specific membrane antigen (PSM) represent additional prostate-specific antigens that are overexpressed only in malignant tumors and therefore are more specific identifiers of malignancies. PSM is an integral membrane protein, and PCTA-1 is related to the galectin gene family, which mediate both cell-cell and cell-matrix interactions in a manner similar to the selectin subgroup of C-type lectins. STEAP is a serpentine transmembrane cell-surface tumor-antigen that is predicted to functions as a channel or transporter protein. In addition to prostate cancers, STEAP is also upregulated in bladder, colon and ovarian cancers.

Function:
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.
Exhibits a dipeptidyl-peptidase IV type activity.

Subcellular Location:
Cytoplasm

Tissue Specificity:
Kidney and liver. Not expressed in the prostate.

Similarity:
Belongs to the peptidase M28 family. M28B subfamily.

Database links:
Entrez Gene: 219595 Human
Omim: 609020 Human
SwissProt: Q9HBA9 Human
Unigene: 645352 Human

FOLH1B,细胞生长抑制蛋白26/前列腺特异性膜抗原样蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.