FITC标记的代谢型谷氨酸受体-3抗体
产品名称： FITC标记的代谢型谷氨酸受体-3抗体
英文名称： Anti-MGLUR3/FITC
产品编号： HZ-12012R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MGLUR3/FITC Conjugated antibody
FITC标记的代谢型谷氨酸受体-3抗体
| 英文名称 | Anti-MGLUR3/FITC |
| 中文名称 | FITC标记的代谢型谷氨酸受体-3抗体 |
| 别 名 | G protein coupled receptor family C group 1 member C; GLUR 3; GLUR3; GLUR3; Glutamate metabotropic receptor 3; Glutamate receptor metabotropic 3; GPRC1C; GRM 3; GRM3; GRM3_HUMAN; Metabotropic glutamate receptor 3; Metabotropic glutamate receptor 3 precursor; mGlu 3; MGlu3; MGlu3; MGLUR 3; MGLUR3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 96kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Metabotropic Glutamate Receptor 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Subunit: nteracts with GRASP Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 3 family. Database links: Entrez Gene: 2913 Human Entrez Gene: 108069 Mouse Entrez Gene: 24416 Rat Omim: 601115 Human SwissProt: Q14832 Human SwissProt: Q9QYS2 Mouse SwissProt: P31422 Rat Unigene: 590575 Human Unigene: 318966 Mouse Unigene: 41715 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
谷氨酸受体介导脑内最兴奋的神经传递，在神经可塑性、神经发育和神经变性中起重要作用。离子型谷氨酸受体分为NMDA受体和海人酸/AMPA受体，它们都含有谷氨酸门控的阳离子特异性离子通道。海藻酸钠/AMPA受体在许多突触中与NMDA受体共定位，由7个结构相关的亚基组成，命名为GluR-1至-7。海人酸钠/AMPA受体主要负责谷氨酸的快速兴奋性神经传递，而NMDA受体的功能特征是缓慢的动力学和高的钙离子渗透性。NMDA受体由五个亚基组成：ε1, 2, 3、4和一个Zeta亚基。Zeta亚单位在脑干中表达，而四个ε亚单位显示有限的分布。