FITC标记的锚蛋白重复结构域蛋白17抗体
产品名称： FITC标记的锚蛋白重复结构域蛋白17抗体
英文名称： Anti-ANKRD17/FITC
产品编号： HZ-9295R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ANKRD17/FITC Conjugated antibody
FITC标记的锚蛋白重复结构域蛋白17抗体
| 产品编号 | bs-9295R-FITC |
| 英文名称 | Anti-ANKRD17/FITC |
| 中文名称 | FITC标记的锚蛋白重复结构域蛋白17抗体 |
| 别 名 | ANKRD 17; ANKRD-17; Ankyrin repeat domain protein 17; Ankyrin repeat domain-containing protein 17; ANR17_HUMAN; FLJ22206; Gene trap ankyrin repeat; Gene trap ankyrin repeat protein; GTAR; KIAA0697; NY BR 16; Serologically defined breast cancer antigen NY-BR-16。 |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 274kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANKRD17 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ANKRD17 is a 2,603 amino acid protein that contains 25 ankyrin repeats and one KH domain. ANKRD17 is expressed in bone marrow and is thought to be involved in liver development. ANKRD17 localizes to the cytoplasm and the nucleus. ANKRD17 exists as five alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 4. Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes. Function: Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification (By similarity). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease). Subunit: Interacts with VP1 capsid protein of enterovirus 71 (EV71). Subcellular Location: Cytoplasm. Nucleus. Detected around the nucleolus. Tissue Specificity: Expressed in bone marrow. Similarity: Contains 25 ANK repeats. Contains 1 KH domain. Database links: Entrez Gene: 9743 Human Omim: 608541 Human SwissProt: A7KAX9 Human Unigene: 440379 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
AKRD17是2603个氨基酸蛋白，含有25个锚蛋白重复序列和一个KH结构域。ANKRD17在骨髓中表达，被认为参与肝脏发育。AKRD17定位于细胞质和细胞核。AKRD17作为五个交替剪接的亚型存在，其编码的基因被映射到人类染色体4。代表人类基因组的6%，4号染色体包含近900个基因。值得注意的是，亨廷顿氏症基因，发现编码的谷氨酰胺通道在亨廷顿氏病的情况下，是在4号染色体上。FGFR-3也编码在4号染色体上，并与致死性侏儒症、软骨发育不全、Munkes综合征和膀胱癌有关。第4号染色体也与Ellis van Creveld综合征、甲基丙二酸血症和多囊肾病有关。据报道，4号染色体含有最大的基因沙漠（基因组中没有蛋白质编码基因的区域），并具有人类染色体的两个最低重组频率之一。