FITC标记的G蛋白偶联受体GPRC5C蛋白抗体
产品名称： FITC标记的G蛋白偶联受体GPRC5C蛋白抗体
英文名称： Anti-GPRC5C/FITC
产品编号： HZ-15394R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPRC5C/FITC Conjugated antibody
FITC标记的G蛋白偶联受体GPRC5C蛋白抗体
| 英文名称 | Anti-GPRC5C/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体GPRC5C蛋白抗体 |
| 别 名 | G-protein coupled receptor family C group 5 member; C; GPC5C; GPRC5C; MGC131820; PSEC0087; RAIG-3; RAIG3; Retinoic acid-induced gene 3 protein; GPC5C_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPRC5C |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPRC5C (G protein-coupled receptor, family C, group 5, member C), also known as RAIG3, is a 441 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and belongs to the G protein-coupled receptor family. Expressed at high levels in stomach, liver, prostate, kidney and pancreas, GPRC5C is thought to function as a retinoic acid-inducible GPR that may play a role in signaling events throughout the cell. GPRC5C is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR. Function: This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles. Tissue Specificity: Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG). Similarity: Belongs to the G-protein coupled receptor 3 family. Database links: Entrez Gene: 55890 Human Entrez Gene: 70355 Mouse Entrez Gene: 287805 Rat Omim: 605949 Human SwissProt: Q9NQ84 Human SwissProt: Q8K3J9 Mouse SwissProt: Q3KRC4 Rat Unigene: 446438 Human Unigene: 242413 Mouse Unigene: 3658 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体(GPR)又称七种跨膜受体、七肽受体或七肽甲基转移酶(7TM)受体，由在许多不同的刺激-反应途径中起作用的蛋白超家族组成。G蛋白偶联受体将细胞外信号翻译成细胞内信号（G蛋白激活），并对多种信号分子作出反应，如激素和神经递质。GPRC5C(G蛋白偶联受体，C家族，第5组，成员C)又称RAIG3，是一种441个氨基酸的多程膜蛋白，定位于细胞质囊泡，属于G蛋白偶联受体家族。在胃、肝、前列腺、肾和胰腺中高表达，GPRC5C被认为是视黄酸诱导的GPR，它可能在整个细胞的信号传导过程中起作用。GPRC5C受DNA损伤依赖的磷酸化，可能是ATM或ATR。