phospho-CREM (Ser271 +Ser 274),磷酸化环磷酸腺苷反应元件调节蛋白抗体

产品编号HZ-4066R
英文名称phospho-CREM (Ser271 +Ser 274)
中文名称磷酸化环磷酸腺苷反应元件调节蛋白抗体
别 名CREM (phospho S271 + S274); p-CREM (phospho S271 + S274); cAMP response element modulator; cAMP responsive element modulator; hCREM 2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 细胞生物 免疫学 转录调节因子 激酶和磷酸酶 结合蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Horse,
phospho-CREM (Ser271 +Ser 274),磷酸化环磷酸腺苷反应元件调节蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CREM around the phosphorylation site of Ser271 +Ser 274
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-CREM (Ser271 +Ser 274),磷酸化环磷酸腺苷反应元件调节蛋白抗体PubMedPubMed
产品介绍background:
CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.

Function:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.

Subunit:
Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.

Post-translational modifications:
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation.

Similarity:
Belongs to the bZIP family.
Contains 1 bZIP domain.
Contains 1 KID (kinase-inducible) domain.

phospho-CREM (Ser271 +Ser 274),磷酸化环磷酸腺苷反应元件调节蛋白抗体Database links:
Entrez Gene: 403887 Dog
Entrez Gene: 1390 Human
Entrez Gene: 12916 Mouse
Entrez Gene: 25620 Rat
Omim: 123812 Human
SwissProt: P79145 Dog
SwissProt: Q03060 Human
SwissProt: P27699 Mouse
SwissProt: Q03061 Rat
Unigene: 200250 Human
Unigene: 10251 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.