FITC标记的细胞核受体Rev-Erbα抗体
产品名称： FITC标记的细胞核受体Rev-Erbα抗体
英文名称： Anti-NR1D1/FITC
产品编号： HZ-20222R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NR1D1/FITC Conjugated antibody
FITC标记的细胞核受体Rev-Erbα抗体
| 英文名称 | Anti-NR1D1/FITC |
| 中文名称 | FITC标记的细胞核受体Rev-Erbα抗体 |
| 别 名 | EAR-1; EAR1; ERBA-RELATED 1; hRev; Nr1d1; NR1D1_HUMAN; Nuclear Receptor Rev-ErbA Alpha; Nuclear receptor subfamily 1 group D member 1; Orphan nuclear receptor NR1D1; Rev erbAalpha; Rev erbalpha; Rev-erbA-alpha; Rev-ErbAalpha; REV-ERBalpha; THRA1; THRAL; Thyroid hormone receptor alpha-like; Thyroid hormone receptor, alpha like; V-erbA related protein EAR-1; V-erbA-related protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NR1D1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NR1D1, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). NR1D1 is a target of Nuclear Receptor ROR Alpha and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Mice lacking NR1D1 show abnormal postnatal cerebellar development. NR1D1 expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, uterus, normal brain, breast, colon, eye, heart, pancreas, pituitary, prostate, skeletal muscle, skin, testis and thyroid. Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription. Possible receptor for triiodothyronine. Subunit: Interacts with C1D and NR2E3. Interacts with SP1. Subcellular Location: Nucleus (Potential). Tissue Specificity: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 9572 Human Entrez Gene: 768225 Cow Entrez Gene: 217166 Mouse Entrez Gene: 252917 Rat Omim: 602408 Human SwissProt: Q08E02 Cow SwissProt: P20393 Human SwissProt: Q3UV55 Mouse SwissProt: Q63503 Rat Unigene: 592130 Human Unigene: 724 Human Unigene: 390397 Mouse Unigene: 29848 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NR1D1，一种NR1甲状腺样受体，由与甲状腺受体α(TR Alpha)基因座相同的基因组位点编码，但从相反的链转录。NR1D1是核受体ROR Alpha和转录调节剂的一个靶点，它已被证明影响心肌细胞分化、脂肪生成和脂蛋白代谢。缺乏NR1D1的小鼠出生后小脑发育异常。NR1D1表达已被记录在人类骨骼肌和各种小鼠和大鼠组织中。已从人体组织文库中分离出EST，包括癌性肾上腺、血液、大脑、乳房、结肠、十二指肠、胎儿、头/颈、肾、肺、骨骼肌、皮肤、滑膜、子宫、正常大脑、乳房、结肠、眼睛、心脏、胰腺、垂体、前列腺、骨骼肌、皮肤、睾丸和甲状腺。