Arginase 1,精氨酸酶1抗体

产品编号HZ-8585R
英文名称Arginase 1
中文名称精氨酸酶1抗体
别 名liver Arginase; ARG 1; ARG1; ARGI1_HUMAN; Arginase1; Arginase liver; Arginase type I; Arginase I; ArginaseI; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
Arginase 1,精氨酸酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Arginase 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 产 商BIOSS
PubMedPubMed
Arginase 1,精氨酸酶1抗体产品介绍background:
Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.

Subunit:
Homotrimer.

Subcellular Location:
Cytoplasm.

DISEASE:
Defects in ARG1 are the cause of argininemia (ARGIN) ; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.

Similarity:
Belongs to the arginase family.

Arginase 1,精氨酸酶1抗体Database links:
Entrez Gene: 513608 Cow
Entrez Gene: 383 Human
Entrez Gene: 11846 Mouse
Entrez Gene: 397115 Pig
Entrez Gene: 100008814 Rabbit
Entrez Gene: 29221 Rat
Omim: 608313 Human
SwissProt: Q2KJ64 Cow
SwissProt: P05089 Human
SwissProt: Q61176 Mouse
SwissProt: Q95JC8 Pig
SwissProt: Q95KM0 Rabbit
SwissProt: P07824 Rat
Unigene: 440934 Human
Unigene: 154144 Mouse
Unigene: 9857 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.