DRAK2,DAP凋亡诱导蛋白激酶2抗体

产品编号HZ-10467R
英文名称DRAK2
中文名称DAP凋亡诱导蛋白激酶2抗体
别 名DAP kinase related apoptosis inducing protein; DAP kinase related apoptosis inducing protein kinase 2; Death associated protein kinase related 2; DRAK 2; Serine/threonine kinase 17b (apoptosis inducing); Serine/threonine kinase 17b; Serine/threonine protein kinase 17B; STK17B; ST17B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
DRAK2,DAP凋亡诱导蛋白激酶2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DRAK2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DRAK2,DAP凋亡诱导蛋白激酶2抗体PubMedPubMed
产品介绍background:
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.

Function:
Acts as a positive regulator of apoptosis.

Subunit:
Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.

Subcellular Location:
Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Note=Colocalizes with STK17B at the plasma membrane.

Tissue Specificity:
Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

DRAK2,DAP凋亡诱导蛋白激酶2抗体Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
DAP kinase subfamily. Contains 1 protein kinase domain.

Gene ID:
9262

Database links:
Entrez Gene: 9262 Human
Entrez Gene: 98267 Mouse
Omim: 604727 Human
SwissProt: O94768 Human
SwissProt: Q8BG48 Mouse
Unigene: 88297 Human
Unigene: 25559 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.