CD206抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
CD206抗体

CD206抗体

商家询价

产品名称： CD206抗体

英文名称： CD206Antibody

产品编号： XY 18704-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 CD206抗体

Applications
In-house applications ELISA, WB, IHC, FC     Application not tested? Please see our Guarantee.
Published applications IHC, WB Publications 3 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Human, mouse, rat
Images
Prev12NextView more validation data
  • 18704-1-AP;human kidney tissuehuman kidney tissue were subjected to SDS PAGE followed by western blot with 18704-1-AP(MRC1 antibody) at dilution of 1:500
  • 18704-1-AP;human liverImmunohistochemical of paraffin-embedded human liver using 18704-1-AP(MRC1 antibody) at dilution of 1:100 (under 10x lens)
  • 18704-1-AP;human liverImmunohistochemical of paraffin-embedded human liver using 18704-1-AP(MRC1 antibody) at dilution of 1:100 (under 40x lens)
  • 18704-1-AP;RAW 264.7 cells1X10^6 RAW 264.7 cells were stained with 0.2ug MRC1 antibody (18704-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
Positive WB detected in Human kidney tissue, HepG2 cells
Positive IHC detected in Human liver tissue
Positive FC detected in RAW 264.7 cells
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 CD206抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information CD206抗体
Immunogen Peptide Full name Mannose receptor, C type 1
Calculated molecular
weight		 166 kDa Observed molecular 
weight		 165-170 kDa, 70 kDa
GenBank accession 
number		 NM_002438 Gene ID (NCBI) 4360
Gene symbol MRC1 Synonyms CD206, CLEC13D, Macrophage mannose receptor 1, Mannose receptor, mannose receptor, C type 1, MMR, MRC1
Background

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1. CD206抗体

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