RABGAP1,Rab蛋白GTP酶激活蛋白1抗体

产品编号HZ-7826R
英文名称RABGAP1
中文名称Rab蛋白GTP酶激活蛋白1抗体
别 名Rab GTPase-activating protein 1; Rab GAP1, GAP and centrosome associated protein; HSPC094; Rab GTPase activating protein 1; Rab6 GTPase activating protein GAPCenA; RBGP1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 细胞类型标志物 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
RABGAP1,Rab蛋白GTP酶激活蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量122kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RABGAP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RABGAP1,Rab蛋白GTP酶激活蛋白1抗体PubMedPubMed
产品介绍background:
Rab GTPase-activating protein 1 is a 1,069 amino acid cytoplasmic protein containing one PID domain and one Rab-GAP TBC domain. Rab GAP1 acts as a GTPase-activating protein of Rab 6A in the Rab 6A-mediated pathway, which is involved in the metaphase-anaphase transition. Expressed as four alternatively spliced variants, Rab GAP1 may also be involved in the microtubule nucleation by centrosome and in Golgi dynamics during the cell cycle. Rab GAP1 is encoded by a gene located on human chromosome 9, which consists of about 145 million bases, 4% of the human genome and encodes nearly 900 genes.

Function:
May act as a GTPase-activating protein of RAB6A. Mayplay a role in microtubule nucleation by centrosome. Mayparticipate in a RAB6A-mediated pathway involved in themetaphase-anaphase transition.

Subunit:
Interacts with RAB6A and tubulin gamma.

Subcellular Location:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton,centrosome. Note=Predominantly cytosolic but also associated withthe centrosome.

Similarity:
Contains 1 PID domain.
Contains 1 Rab-GAP TBC domain.

Gene ID:
23637

Database links:
Entrez Gene: 519260 Cow
Entrez Gene: 23637 Human
Entrez Gene: 227800 Mouse
Entrez Gene: 311911 Rat
SwissProt: Q9Y3P9 Human
SwissProt: A2AWA9 Mouse
Unigene: 271341 Human
Unigene: 383192 Mouse
Unigene: 14944 Rat

RABGAP1,Rab蛋白GTP酶激活蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.