GFR alpha 3,GDNF家族受体α3抗体

产品编号HZ-11501R
英文名称GFR alpha 3
中文名称GDNF家族受体α3抗体 GFR α3
别 名GFRA3; GDNF family receptor alpha 3; GDNF Receptor alpha 3; GFR alpha 3; GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3; GFRA3; GFRA3_HUMAN; Glial cell line derived neurotrophic factor receptor alpha 3; GPI linked receptor.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
GFR alpha 3,GDNF家族受体α3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GFR alpha 3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GFR alpha 3,GDNF家族受体α3抗体PubMedPubMed
产品介绍background:
Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF Beta superfamily of growth factors. Three receptors for these factors, GFR Alpha-1 (also designated GDNFR-Alpha, RETL1 or TrnR-1), GFR Alpha-2 (also designated GDNFR-Beta, RETL2, NTNR-Alpha or TrnR-2) and GFR Alpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR Alpha-1 and GFR Alpha-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR Alpha-3 is expressed only during development.

Function:
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the GDNFR family.

Database links:
Entrez Gene: 2676 Human
Entrez Gene: 14587 Mouse
Entrez Gene: 84422 Rat
Omim: 605710 Human
SwissProt: O60609 Human
SwissProt: O35118 Mouse
Unigene: 58042 Human
Unigene: 16520 Mouse
Unigene: 15499 Rat

GFR alpha 3,GDNF家族受体α3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.