FITC标记的微管蛋白β4抗体
产品名称： FITC标记的微管蛋白β4抗体
英文名称： Anti-beta IV Tubulin/FITC
产品编号： HZ-12861R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-beta IV Tubulin/FITC Conjugated antibody
FITC标记的微管蛋白β4抗体
| 英文名称 | Anti-beta IV Tubulin/FITC |
| 中文名称 | FITC标记的微管蛋白β4抗体 |
| 别 名 | Beta 4; Beta 4 tubulin; beta 5; MC1R; TBB4_HUMAN; TUB B4; TUBB 4; TUBB4; TUBB5; Tubulin 5 beta; Tubulin beta 3; Tubulin beta 4; Tubulin beta 4 chain; Tubulin beta 5; Tubulin beta IV; Tubulin beta-4 chain. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞类型标志物 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TUBB4/beta IV Tubulin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Subunit: Dimer of alpha and beta chains. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Post-translational modifications: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules. Similarity: Belongs to the tubulin family. Database links: Entrez Gene: 10382 Human Entrez Gene: 22153 Mouse Entrez Gene: 29213 Rat Omim: 602662 Human SwissProt: P04350 Human SwissProt: Q9D6F9 Mouse Unigene: 110837 Human Unigene: 7420 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
βIII微管蛋白在中枢和外周神经系统（CNS和PNS）中含量丰富，在胎儿和产后发育过程中显著表达。如小脑和交感肾上腺神经发生的例子，βIII的分布是神经元相关的，根据起源的区域性神经上皮表现出明显的时空梯度。然而，该蛋白的瞬时表达也存在于包括推测的神经元和/或胶质前体细胞的中枢神经系统的室下区，以及胎儿呼吸上皮的Kulchitsky神经内分泌细胞中。这种时间上受限的、潜在的非神经元表达可能在鉴定来自胚胎干细胞的假定神经元方面具有意义。