NTR1 (H218) Antibody
产品名称: NTR1 (H218) Antibody
英文名称: NTR1 (H218) Antibody
产品编号: BS2820
产品价格: null
产品产地: USA
品牌商标: Bioworld
更新时间: null
使用范围: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
巴傲得生物科技有限公司
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- 邮编 : 210036
- 所在区域 : 上海
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- 邮箱 : order@biogot.com
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1β and TNFα in an ERK1/2 and Akt kinase-dependent manner.