Cathepsin H,组织蛋白酶H抗体

产品编号HZ-1670R
英文名称Cathepsin H
中文名称组织蛋白酶H抗体
别 名CTSH; Cathepsin H; Activation peptide; ACC4; ACC5; CPSB; cath-H; CH; Ctsh; CATH_HUMAN; Pro-cathepsin H.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 转录调节因子 合成与降解
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
Cathepsin H,组织蛋白酶H抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量8/35kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Cathepsin H Activation peptide
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Cathepsin H,组织蛋白酶H抗体PubMedPubMed
产品介绍background:
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in various cellular events such as peptide biosynthesis and protein degradation. The propeptide region of cathepsin H is highly homologous to other cathepsins. This region is thought to play a role in the processing of cysteine proteases. Cathepsin H is thought to be involved in several pathological conditions, including neuro degenerative disorders and cancer.

Function:
Important for the overall degradation of proteins in lysosomes.

Subunit:
Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.

Subcellular Location:
Lysosome.

Similarity:
Belongs to the peptidase C1 family.

Gene ID:
1512

Cathepsin H,组织蛋白酶H抗体Database links:
Entrez Gene: 1512 Human
Entrez Gene: 25425 Rat
Omim: 116820 Human
SwissProt: P09668 Human
SwissProt: P00786 Rat
Unigene: 148641 Human
Unigene: 1997 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.