Eph receptor A5,酪氨酸蛋白激酶A5受体抗体

产品编号HZ-6599R
英文名称Eph receptor A5
中文名称酪氨酸蛋白激酶A5受体抗体
别 名bsk; CEK 7; Eck like sequence 1; EHK 1; Els 1; Eph homology kinase 1; EphA5; Ephrin type A receptor 5; HEK 7; Receptor protein tyrosine kinase HEK 7; Rek 7; TYRO 4; Tyrosine protein kinase receptor EHK 1; EPHA5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 发育生物学 神经生物学 信号转导 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Guinea Pig,
Eph receptor A5,酪氨酸蛋白激酶A5受体抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量114kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EphA5/Eph receptor A5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Eph receptor A5,酪氨酸蛋白激酶A5受体抗体PubMedPubMed
产品介绍background:
EphA5, also known as Ehk1, Bsk, Cek7, Hek7, and Rek7, is a member of the Eph receptor family, which binds members of the Ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region is a juxtamembrane region with two tyrosines, the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the C-terminus, the latter including one conserved tyrosine.

Subunit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Tissue Specificity:
Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.

Eph receptor A5,酪氨酸蛋白激酶A5受体抗体Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.

Database links:
Entrez Gene: 2044 Human
Entrez Gene: 13839 Mouse
Entrez Gene: 79208 Rat
Omim: 600004 Human
SwissProt: P54755 Chicken
SwissProt: P54756 Human
SwissProt: Q60629 Mouse
SwissProt: P54757 Rat
Unigene: 654492 Human
Unigene: 137991 Mouse
Unigene: 438006 Mouse
Unigene: 24569 Rat

Eph receptor A5,酪氨酸蛋白激酶A5受体抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.