FITC标记的周期素依赖性激酶样5抗体
产品名称： FITC标记的周期素依赖性激酶样5抗体
英文名称： Anti-CDKL5/FITC
产品编号： HZ-11538R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CDKL5/FITC Conjugated antibody
FITC标记的周期素依赖性激酶样5抗体
| 产品编号 | bs-11538R-FITC |
| 英文名称 | Anti-CDKL5/FITC |
| 中文名称 | FITC标记的周期素依赖性激酶样5抗体 |
| 别 名 | Cdkl5; CDKL5_HUMAN; Cyclin dependent kinase 5 transcript; Cyclin-dependent kinase-like 5; EIEE2; ISSX; Serine/threonine kinase 9; Serine/threonine-protein kinase 9; Stk9. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 115kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDKL5 (401-500aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin-dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. CDKL5 (cyclin-dependent kinase-like 5) is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome and Rett syndrome. Function: Mediates phosphorylation of MECP2. Subunit: Interacts with MECP2. Subcellular Location: Nucleus. Tissue Specificity: Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis. Post-translational modifications: Autophosphorylated. DISEASE: Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15). Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 (EIEE2) [MIM:300672]; also known as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: O76039.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞周期的进展部分由细胞周期蛋白家族和细胞周期蛋白依赖性激酶（CDKs）控制。CDK蛋白与细胞周期蛋白协同作用，以磷酸化参与细胞周期进程各阶段的关键底物。另一类蛋白质，CDK抑制剂，也起到调节细胞周期的作用，与细胞周期蛋白CDK复合物结合并调节它们的活性。CDKL5（cyclin依赖性激酶样5）是属于CMGC SE/THR蛋白激酶家族的1030氨基酸蛋白。CDKL5在脑、肺、肾、前列腺、卵巢、胎盘、胰腺和睾丸中均有表达，在细胞周期调控中起重要作用。CDKL5的缺陷是多种疾病的原因，如X-连锁婴儿痉挛综合征和雷特综合征。