RBP4抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
RBP4抗体

RBP4抗体

商家询价

产品名称： RBP4抗体

英文名称： RBP4Antibody

产品编号： XY11774-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 RBP4抗体Applications

In-house applications ELISA, IHC, WB     Application not tested? Please see our Guarantee.
Published applications WB Publications 2 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human, mouse
Images
Prev1NextView more validation data
  • 11774-1-AP;human liver cancerImmunohistochemical of paraffin-embedded human liver cancer using 11774-1-AP(RBP4 antibody) at dilution of 1:50 (under 10x lens)
  • 11774-1-AP;human liver cancerImmunohistochemical of paraffin-embedded human liver cancer using 11774-1-AP(RBP4 antibody) at dilution of 1:50 (under 40x lens)
  • 11774-1-AP;human plasma tissuehuman plasma tissue were subjected to SDS PAGE followed by western blot with 11774-1-AP( RBP4 Antibody) at dilution of 1:1000
Positive WB detected in Human plasma tissue, human liver tissue, mouse liver tissue, rat liver tissue
Positive IHC detected in Human liver cancer tissue, mouse liver tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
 RBP4抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information RBP4抗体
Immunogen RBP4 fusion protein ag2448 Full name Retinol binding protein 4, plasma
Calculated molecular
weight		 201aa,23 kDa Observed molecular 
weight		 23 kDa
GenBank accession 
number		 BC020633 Gene ID (NCBI) 5950
Gene symbol RBP4 Synonyms Plasma retinol binding protein, PRBP, RBP, RBP4, Retinol binding protein 4
Background

RBP4 (retinol-binding protein 4) is a carrier protein that transports vitamin A (retinol) from the liver to the peripheral tissues. Synthesized primarily by hepatocytes and adipocytes as a 21 kDa non-glycosylated protein, RBP4 is secreted into the circulation as a retinol-RBP4 complex. In plasma the RBP4-retinol complex is bound to transthyretin (TRR), which prevents prevent kidney filtration. Two truncated forms of RBP4, RBP4-L (truncated at Leu-183) and RBP4-LL (truncated at Leu-182 and Leu-183), exist by proteolytic process. RBP4-L and RBP4-LL, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. Urinary RBP4 has been reported as marker for glomerular disease. RBP4 also was identified as an adipokine that elevated in some insulin-resistant states. Measurement of serum RBP4 could be used to assess the risk of insulin resistance, type 2 diabetes, obesity, and cardiovascular disease. (18752671, 16034410) RBP4抗体

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