FITC标记的转运蛋白SEC63抗体
产品名称： FITC标记的转运蛋白SEC63抗体
英文名称： Anti-SEC63/FITC
产品编号： HZ-19620R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SEC63/FITC Conjugated antibody
FITC标记的转运蛋白SEC63抗体
| 英文名称 | Anti-SEC63/FITC |
| 中文名称 | FITC标记的转运蛋白SEC63抗体 |
| 别 名 | ERdj2; PRO2507; SEC 63; SEC63L; Translocation protein SEC63 homolog. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SEC63 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008] Function: SEC63 and SEC62 proteins are found to be associated with the ribosome-free SEC61 complex, which is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Mutations in SEC63 cause autosomal dominant polycystic liver disease. Subcellular Location: Endoplasmic reticulum membrane; Multi pass membrane protein. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:A hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. Database links: Entrez Gene: 11231 Human Entrez Gene: 140740 Mouse Entrez Gene: 309858 Rat Omim: 608648 Human SwissProt: Q9UGP8 Human SwissProt: Q8VHE0 Mouse Unigene: 26904 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SEC61复合物是内质网（ER）膜蛋白质转运装置的中心组成部分。该基因编码的蛋白和SEC62蛋白与核糖体游离SEC61复合物相关。推测SEC61-SEC62-SEC63可以在ER中进行翻译后蛋白质易位。Sec61-Sec62-Sec63复合物还可能执行ER蛋白的向后转运，这些蛋白受到泛素-蛋白酶体依赖的降解途径。编码的蛋白质是位于粗糙ER中的一种完整的膜蛋白。[ RefSeq，JUL 2008 ]