FITC标记的HECA蛋白抗体
产品名称： FITC标记的HECA蛋白抗体
英文名称： Anti-HECA/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-HECA/FITC Conjugated antibody
FITC标记的HECA蛋白抗体
| 产品编号 | bs-9702R-FITC |
| 英文名称 | Anti-HECA/FITC |
| 中文名称 | FITC标记的HECA蛋白抗体 |
| 别 名 | HDCL; Gm869; HDC; HDC_HUMAN; Headcase homolog (Drosophila); Headcase protein homolog; HECA; hHDC. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 神经生物学 细胞周期蛋白 细胞分化 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HECA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HECA, also known as headcase homolog, HDC, HDCL or HHDC, is a 543 amino acid mammalian homolog of the Drosophila headcase protein, a highly basic, cytplasmic peptide that plays a role in mitotic re-entry during adult morphogenesis. Expressed in a variety of tissues with highest expression in thymus, spleen and heart, HECA is thought to play a role in the development of epithelial tube networks in lung tissue and may also be involved in the pathogenesis of lung cancer. The gene encoding HECA maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. Function: May play an important role in some human cancers. May bepart of the regulatory mechanism in the development of epithelialtube networks such as the circulatory system and lungs. Tissue Specificity: Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas. Database links: Entrez Gene: 51696 Human Entrez Gene: 380629 Mouse Entrez Gene: 308624 Rat Omim: 607977 Human SwissProt: Q9UBI9 Human Unigene: 197644 Human Unigene: 473073 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HECA，也称为头盖同源物，HDC，HDCL或HHDC，是果蝇头壳蛋白的543氨基酸哺乳动物同源物，是一种高度基本的细胞质肽，在形态发生过程中有丝分裂再入中起作用。在胸腺、脾脏和心脏中表达最高的各种组织中，HECA被认为在肺组织上皮管网络的发育中起作用，也可能参与肺癌的发病机制。编码HeCa的基因映射到人类6号染色体，其包含1亿7000万个碱基对，并包含人类基因组的近6%。缺失6号染色体Q臂的一部分与早期发病的肠癌相关，提示存在癌症易感性位点。此外，Porphyria迟发性皮肤白斑、帕金森病、Stutk勒综合征和双相情感障碍的易感性都与映射到6号染色体的基因相关。