DERL3,内质网退化蛋白3抗体

产品编号HZ-14281R
英文名称DERL3
中文名称内质网退化蛋白3抗体
别 名C22orf14; Degradation in endoplasmic reticulum protein 3; DER 3; Der1 like domain family member 3; Der1 like protein 3; Der1-like protein 3; DER3; DERL 3; Derl3; DERL3_HUMAN; Derlin 3; Derlin 3 protein; Derlin-3; Derlin3; DERtrin 3; DERtrin-3; DERtrin3; IZP 6; IZP6; LLN 2; LLN2; MGC71803.
说 明 书0.1ml 0.2ml
研究领域信号转导 转运蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit,
DERL3,内质网退化蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DERL3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DERL3,内质网退化蛋白3抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Function:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.

Similarity:
Belongs to the derlin family.

Gene ID:
91319

DERL3,内质网退化蛋白3抗体Database links:
Entrez Gene: 91319 Human
Entrez Gene: 614334 Cow
Entrez Gene: 70377 Mouse
Omim: 610305 Human
SwissProt: Q0P5E4 Cow
SwissProt: Q96Q80 Human
SwissProt: Q9D8K3 Mouse
Unigene: 593679 Human
Unigene: 275878 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.