ZNF312B,锌指蛋白321B抗体

产品编号HZ-11498R
英文名称ZNF312B
中文名称锌指蛋白321B抗体
别 名FEZF1; FEZ; FEZ family zinc finger 1; Fez family zinc finger protein 1; fez like; fezf1; FEZF1_HUMAN; Zinc finger protein 312 like; Zinc finger protein 312B.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 发育生物学 神经生物学 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
ZNF312B,锌指蛋白321B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ZNF312B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ZNF312B,锌指蛋白321B抗体PubMedPubMed
产品介绍background:
Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.

Function:
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in brain. Little or no expression in other tissues. Overexpresssed specifically in gastic cancers. A 2-to 20-fold increase is found in over 50% of gastric cancer tissues.

ZNF312B,锌指蛋白321B抗体Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 6 C2H2-type zinc fingers.

Gene ID:
389549

Database links:
Entrez Gene: 389549 Human
Entrez Gene: 73191 Mouse
SwissProt: A0PJY2 Human
SwissProt: Q0VDQ9 Mouse
Unigene: 553970 Human
Unigene: 55115 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.