ABCG1,三磷酸腺苷结合盒亚家族G1抗体

产品编号HZ-1231R
英文名称ABCG1
中文名称三磷酸腺苷结合盒亚家族G1抗体
别 名ABC transporter 8; Abc8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub family G WHITE member 1; homolog of Drosophila white; MGC34313; White protein homolog; White protein homolog ATP binding cassette transporter 8; ABC8; ABCG1; ABCG1_HUMAN; ATP-binding cassette sub family G member 1; WHT1; WHITE1; wht1.
规格价格0.1ml 0.2ml
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 信号转导 新陈代谢
抗体来源Rabbit
ABCG1,三磷酸腺苷结合盒亚家族G1抗体克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量76kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ABCG1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ABCG1,三磷酸腺苷结合盒亚家族G1抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.

Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

Subunit:
May form heterodimers with several heterologous partners of the ABCG subfamily.

Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.

ABCG1,三磷酸腺苷结合盒亚家族G1抗体Tissue Specificity:
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

Post-translational modifications:
Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.

Similarity:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.

Gene ID:
9619

Database links:
Entrez Gene: 510745 Cow
Entrez Gene: 9619 Human
Entrez Gene: 85264 Rat
Omim: 603076 Human
SwissProt: P45844 Human
Unigene: 124649 Human
Unigene: 8398 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ABCG1是ABC转运蛋白家族中的成员，是位于组织浆膜中的单体转运蛋白，多分布于肝、小肠、胎盘、脂肪和脾.主要用于脂质/脂蛋白代谢与动脉粥样硬化方面的研究.

产品图片

Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-ABCG1 Polyclonal Antibody, Unconjugated(bs-1231R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining