FITC标记的磷酸化乙酰辅酶A羧化酶抗体
产品名称： FITC标记的磷酸化乙酰辅酶A羧化酶抗体
英文名称： Anti-Phospho-Acetyl Coenzyme A carboxylase alpha (Ser78)/FITC
产品编号： HZ-3036R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-Acetyl Coenzyme A carboxylase alpha (Ser78)/FITC Conjugated antibody
FITC标记的磷酸化乙酰辅酶A羧化酶抗体
| 英文名称 | Anti-Phospho-Acetyl Coenzyme A carboxylase alpha (Ser78)/FITC |
| 中文名称 | FITC标记的磷酸化乙酰辅酶A羧化酶抗体 |
| 别 名 | Acetyl Coenzyme A Carboxylase alpha (phospho S78); p-Acetyl Coenzyme A Carboxylase alpha (phospho S78); ACAC; ACACA; ACACA; ACACA_HUMAN; ACC alpha; ACC; ACC-alpha; ACC1; ACC1; ACCA; acetyl CoA carboxylase 1; acetyl Coenzyme A; Acetyl Coenzyme A; Biotin carboxylase; Acetyl-Coenzyme A Carboxylase alpha. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 免疫学 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 266kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Acetyl Coenzyme A carboxylase alpha around the phosphorylation site of Ser78 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Subunit: Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. Post-translational modifications: Phosphorylation on Ser-1263 is required for interaction with BRCA1. DISEASE: Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth. Similarity: Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain. Database links: Entrez Gene: 31 Human Entrez Gene: 32 Human Omim: 200350 Human SwissProt: O00763 Human SwissProt: Q13085 Human Unigene: 160556 Human Unigene: 234898 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Acetyl CoA carboxylase（ACC）是一种复杂的多功能酶系统。ACC是一种含生物素的酶，它催化乙酰辅酶A羧化为丙二酰辅酶A，这是脂肪酸合成中的限速步骤。有两种ACC形式，α和β，由两种不同的基因编码。ACCα在脂肪组织中高度富集。该酶长期处于转录和翻译水平，并在短期调控下通过靶向丝氨酸残基的磷酸化/去磷酸化和柠檬酸盐或棕榈酰辅酶A的变构转化。在该基因中发现了多个交替编码的转录变体，在5’序列中发散并编码不同的亚型。[ RefSeq，JUL 2008 ]提供。