EF-1 (elongation factor-1) is a multi-protein complex that is responsible for
the delivery of aminoacyl-tRNAs to the ribosome. EF-1 γ (elongation factor-
1 γ), also known as EEF1G or GIG35, is a 437 amino acid subunit of the EF-1
complex. Expressed in stomach, pancreas, brain, lung, kidney, intestine, liver
and spleen, EF-1 γ contains an N-terminal Glutathione transferase domain
which is thought to be involved in anchoring the complex to various cellular
components. Additionally, EF-1 γ may play a key role in the assembly of multiprotein
complexes containing aminoacyl-tRNA synthetases. Increased expression
of EF-1 γ is associated with pancreatic cancer, suggesting a possible role
for EF-1 γ in the oncogenic transformation process.