FITC标记的肥大细胞类糜蛋白酶1抗体
产品名称： FITC标记的肥大细胞类糜蛋白酶1抗体
英文名称： Anti-Mast Cell Chymase/FITC
产品编号： HZ-2353R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200
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Rabbit Anti-Mast Cell Chymase/FITC Conjugated antibody
FITC标记的肥大细胞类糜蛋白酶1抗体
| 英文名称 | Anti-Mast Cell Chymase/FITC |
| 中文名称 | FITC标记的肥大细胞类糜蛋白酶1抗体 |
| 别 名 | CHYMASE; Alpha-chymase; Chymase 1; Chymase 1 mast cell; Chymase; Chymase, heart; Chymase, mast cell; CMA1; CMA1_HUMAN; CYH; CYM; EC 3.4.21.39; Mast cell chymase 1; Mast cell protease 3; Mast cell protease 5; Mast cell protease I; Mast cell protease III; Mcp-5; MCP3P; Mcpt5; MCT1; MGC119890; MGC119891; MMCP-5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Sheep, Guinea Pig, |
| 产品应用 | Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Mast Cell Chymase |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Subcellular Location: Secreted. Cytoplasmic granule. Note=Mast cell granules. Tissue Specificity: Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. Similarity: Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain. Database links:
Entrez Gene: 1215 Human Entrez Gene: 17228 Mouse Omim: 118938 Human SwissProt: P23946 Human SwissProt: P21844 Mouse Unigene: 135626 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因产物是属于肽酶家族S1的糜蛋白酶丝氨酸蛋白酶。它在肥大细胞中表达，并认为在细胞外基质降解、粘膜下腺体分泌的调节和血管活性肽的生成中起作用。在心脏和血管中，这种蛋白质，而不是血管紧张素转换酶，主要负责将血管紧张素I转化为血管活性肽血管紧张素II。Angiotensin II参与了血压控制和高血压、心肌肥厚和心力衰竭的发病机制。因此，该基因产物是心血管疾病治疗的靶点。该基因在编码其他蛋白酶的基因簇中映射到14q11.2。[ RefSeq，JUL 2008 ]