FITC标记的人脑钠素单克隆抗体
产品名称： FITC标记的人脑钠素单克隆抗体
英文名称： Anti-BNP(H1G3)/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Mouse Anti-BNP(H1G3)/FITC Conjugated antibody
FITC标记的人脑钠素单克隆抗体
| 英文名称 | Anti-BNP(H1G3)/FITC |
| 中文名称 | FITC标记的人脑钠素单克隆抗体 |
| 别 名 | BNP 32; Brain natriuretic peptide 32; Gamma brain natriuretic peptide; Natriuretic peptide brain type; Natriuretic peptide precursor B; Natriuretic peptides B; NPPB; NPPB protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 免疫学 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | H1G3 |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BNP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity. Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Subcellular Location: Secreted. Tissue Specificity: Brain and also in atria, but at much lower levels than ANP. Similarity: Belongs to the natriuretic peptide family. Database links: Entrez Gene: 4879 Human Omim: 600295 Human SwissProt: P16860 Human Unigene: 219140 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脑钠素主要是心脏，心脏作为内分泌器官释放脑钠素，调解体液及电解质内环境的恒定性。 B型利钠肽（钠尿肽）（B－typenatriureticpeptide，BNP），又称脑钠素或脑钠肽，因其有排钠利尿、内皮非依赖性的血管平滑肌作用而具有降压、抗心肌纤维化、影响神经内分泌系统等功效。 近来发现BNP在各种心血管疾病，尤其是心室功能不全、急性心肌梗死（ami）、高血压等疾病的诊断、治疗及预后等方面有重要意义，已引起临床工作者的高度重视 |
脑钠肽（BNP）作为血液中的肽类在血液中循环，具有利钠肽、血管舒张和肾素抑制的特性。BNP主要是由左心室肌细胞分泌的，对体积膨胀和压力超负荷作出反应。BNP属于结构相似的肽类家族，包括心钠素（ANP）、BNP、C型利钠肽（CNP）和尿毒症。这些肽的特征在于两个半胱氨酸残基之间具有二硫键的共同的17氨基酸环结构。该环结构在不同利钠肽之间显示出高度同源性（17个氨基酸残基中的十一个在每个利钠肽的环中同源）。BNP是半胱氨酸残基Cys10和Cys26之间具有二硫键的32氨基酸肽。早先的研究表明，血中BNP浓度随着充血性心力衰竭的严重程度而增加。血液中BNP的定量测定是充血性心力衰竭严重程度的客观指标。