FITC标记的CGG结合蛋白1抗体
产品名称： FITC标记的CGG结合蛋白1抗体
英文名称： Anti-CGGBP1/FITC
产品编号： HZ-13879R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CGGBP1/FITC Conjugated antibody
FITC标记的CGG结合蛋白1抗体
| 英文名称 | Anti-CGGBP1/FITC |
| 中文名称 | FITC标记的CGG结合蛋白1抗体 |
| 别 名 | 20 kDa CGG binding protein; 20 kDa CGG-binding protein; CGBP1_HUMAN; CGG binding protein 1; CGG triplet repeat binding protein 1; CGG triplet repeat-binding protein 1; CGG-binding protein 1; CGGBP 1; CGGBP; Cggbp1; OTTHUMP00000213853; OTTHUMP00000213877; p20 CGG binding protein; p20 CGGBP; p20 CGGBP DNA binding protein; p20-CGGBP DNA-binding protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CGGBP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 (fragile X mental retardation) gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5’-untranslated region of the gene which, in fragile X syndrome, is substantially amplified and subject to extensive methylation and enhanced transcriptional silencing. CGGBP1 (CGG triplet repeat binding protein 1), also known as CGGBP or p20-CGGBP, is a 167 amino acid nuclear protein that influences FMR1 expression. Highly expressed in thymus, placenta, lymph nodes, cerebral cortex and cerebellum, CGGBP1 binds to the 5’ (CGG)n-3’ repeat in the promotor of the FMR1 gene and positively regulates expression of the FMR1 protein. Binding of CGGBP1 to the FMR1 promoter is inhibited by cytosine-specific DNA methylation of the protein binding motif, suggesting that CGGBP1 activity is silenced in FMR1-affected individuals. Function: Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Database links: Entrez Gene: 8545 Human Omim: 603363 Human SwissProt: Q9UFW8 Human Unigene: 444818 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
脆性X综合征是遗传性智力低下最常见的形式，是X染色体上FMR1（脆性X智力低下）基因转录沉默的结果。FMR1基因包含一个独特的CpG二核苷酸重复序列，位于该基因的5’非翻译区，在脆性X综合征中，该基因被显著扩增并经受广泛的甲基化和增强的转录沉默。CGGBP1（CGG三重重复结合蛋白1），又称CGGBP或p20-CGGBP，是一种影响FMR1表达的167个氨基酸核蛋白。CGBP1在胸腺、胎盘、淋巴结、大脑皮层和小脑中高度表达，与FMR1基因启动子中的5’(CGG)n-3’重复序列结合，并正向调节FMR1蛋白的表达。CGGBP1与FMR1启动子的结合受到蛋白结合基序胞嘧啶特异性DNA甲基化的抑制，表明受FMR1影响的个体中CGGBP1活性被抑制。