RAF1 monoclonal antibody, clone 4G4
产品名称: RAF1 monoclonal antibody, clone 4G4
英文名称: RAF1 monoclonal antibody, clone 4G4
产品编号: MAB10310
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant RAF1.
- Immunogen:
- Recombinant protein corresponding to human RAF1.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.5% protein stabilizer, 0.05% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
Flow cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis using RAF1 monoclonal antobody, clone 4G4 (Cat # MAB10310) against HeLa (1), A-431 (2), COS-7 (3) and C6 (4) cell lysate.
- Western Blot (Recombinant protein)
- Western blot analysis using RAF1 monoclonal antobody, clone 4G4 (Cat # MAB10310) against recombinant human RAF1 protein.
- Entrez GeneID:
- 5894
- Gene Name:
- RAF1
- Gene Alias:
- CRAF,NS5,Raf-1,c-Raf
- Gene Description:
- v-raf-1 murine leukemia viral oncogene homolog 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq
- Other Designations:
- Oncogene RAF1,raf proto-oncogene serine/threonine protein kinase
- Interactome
- Gene Pathway
- Acute myeloid leukemia
- B cell receptor signaling pathway
- Bladder cancer
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Related Disease
- Abnormalities, Multiple
- Arrhythmias, Cardiac
- Articulation Disorders
- Cardiovascular Diseases
- Cognition
- Cognition Disorders
- Developmental Disabilities
- Diabetes Mellitus, Type 2
- Dyslexia, Acquired
- Edema
- Genetic Predisposition to Disease
- Glioma
- Hearing
- Heart Defects, Congenital
- Hypertrophy, Left Ventricular
- Language Disorders
- LEOPARD Syndrome
- Memory
- Motor Skills