IRAK4 (C-term) Peptide
产品名称： IRAK4 (C-term) Peptide
英文名称： IRAK4 (C-term) Peptide
产品编号： P2810
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of IRAK4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human IRAK4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections.
Medvedev AE, Lentschat A, Kuhns DB, Blanco JC, Salkowski C, Zhang S, Arditi M, Gallin JI, Vogel SN.J Exp Med. 2003 Aug 18;198(4):521-31.
- 2.
- Pyogenic bacterial infections in humans with IRAK-4 deficiency.
Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah S, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, Casanova JL.Science. 2003 Mar 28;299(5615):2076-9. Epub 2003 Mar 13.
- 3.
- Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X.J Biol Chem. 2003 Mar 28;278(13):10952-6. Epub 2002 Dec 20.
- Entrez GeneID:
- 51135
- Protein Accession#:
- NP_057207
- Gene Name:
- IRAK4
- Gene Alias:
- IPD1,NY-REN-64,REN64
- Gene Description:
- interleukin-1 receptor-associated kinase 4
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq
- Other Designations:
- IRAK-4 mutated form 1,interleukin-1 receptor associated kinase 4
- Related Disease
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Birth Weight
- Bronchiolitis, Viral
- Cardiovascular Diseases
- Chronic Disease
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Glioblastoma
- Glioma
- HIV Infections
- Hypersensitivity
- Infant, Premature, Diseases