TAF1 (Human) Recombinant Protein (Q01)
产品名称： TAF1 (Human) Recombinant Protein (Q01)
英文名称： TAF1 (Human) Recombinant Protein (Q01)
产品编号： H00006872-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human TAF1 partial ORF ( NP_004597, 1784 a.a. - 1893 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- RMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE
- Theoretical MW (kDa):
- 37.84
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 6872
- GeneBank Accession#:
- NM_004606
- Protein Accession#:
- NP_004597
- Gene Name:
- TAF1
- Gene Alias:
- BA2R,CCG1,CCGS,DYT3,KAT4,N-TAF1,NSCL2,OF,P250,TAF2A,TAFII250
- Gene Description:
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq
- Other Designations:
- OTTHUMP00000024334,TBP-associated factor 1,cell cycle, G1 phase defect,complementation of cell cycle block, G1-to-S,transcription factor TFIID p250 polypeptide
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Angina, Unstable
- Atherosclerosis
- Cardiovascular Diseases
- Coronary Disease
- Diabetes Complications
- Genetic Predisposition to Disease
- Graft Occlusion, Vascular
- Hemolytic-Uremic Syndrome
- Inflammation
- Intracranial Thrombosis
- Leukemia
- Lymphoma, Non-Hodgkin
- Meningococcal Infections
- Metabolic Syndrome X
- Myocardial Infarction
- Neoplasms
- Osteoporosis