FITC标记的突触融合蛋白6抗体
产品名称： FITC标记的突触融合蛋白6抗体
英文名称： Anti-Syntaxin 6/FITC
产品编号： HZ-11261R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Syntaxin 6/FITC Conjugated antibody
FITC标记的突触融合蛋白6抗体
| 产品编号 | bs-11261R-FITC |
| 英文名称 | Anti-Syntaxin 6/FITC |
| 中文名称 | FITC标记的突触融合蛋白6抗体 |
| 别 名 | STX 6; STX6; STX-6; STX6_HUMAN; Syntaxin-6; Syntaxin6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Syntaxin 6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain carboxy-terminal hydrophobic domains that direct themselves to their respective intracellular compartments. Synaptin 6 is a 255 amino acid protein that is widely expressed, with higher expression levels in brain, lung and kidney. This synaptin co-localizes with vesicle associated membrane protein (VAMP) 4 to tubular and vesicular membranes of the Golgi apparatus. The cytosolic domain of Syntaxin 6 reduces the rate on Glut4 reinternalization upon insulin withdrawl and is involved in a memrane-trafficking process that removes Glut4 from traffic directed to the plasma membrane. Syntaxin 6 is upregulated in activated macrophages in conjunction with an increase in the secretion of cytokines. The delivery of microdomain-associated lipids and proteins to the cell surface is regulated by Syntaxin 6. Function: Involved in intracellular vesicle trafficking. Subunit: Binds EEA1. Interacts with VPS45A. Interacts with MARCH2 and MARCH3 (By similarity). Interacts with GOPC. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. Subcellular Location: Golgi apparatus membrane. Similarity: Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain. Database links: UniProtKB/Swiss-Prot: O43752.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
突触蛋白是突触囊泡与质膜融合的一个蛋白家族，显示出广泛的组织分布，并含有羧基末端的疏水结构域，它们将自身引导到它们各自的细胞内室。突触蛋白6是一种广泛表达的255种氨基酸，在脑、肺和肾中具有较高的表达水平。该突触蛋白与囊泡相关膜蛋白（VAMP）4共同定位到高尔基体的管状和泡状膜。突触结合蛋白6的胞质结构域降低GLUT4在胰岛素撤回后再内化的速率，并参与膜转运过程，从转运到质膜的交通中去除GLUT4。Sythin 6在活化的巨噬细胞中上调，结合细胞因子的分泌增加。微结构域相关脂质和蛋白质向细胞表面的递送由Sythin 6调节。