FITC标记的溶质载体家族17成员5抗体
产品名称： FITC标记的溶质载体家族17成员5抗体
英文名称： Anti-SLC17A5/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SLC17A5/FITC Conjugated antibody
FITC标记的溶质载体家族17成员5抗体
| 英文名称 | Anti-SLC17A5/FITC |
| 中文名称 | FITC标记的溶质载体家族17成员5抗体 |
| 别 名 | AST; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; ISSD; Membrane glycoprotein HP59; NSD; S17A5_HUMAN; SD; Sialic acid storage disease; Sialin; SIASD; Slc17a5; SLD; Solute carrier family 17 (anion/sugar transportermember 5; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporter. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC17A5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008] Function: Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. Subcellular Location: Cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane. Tissue Specificity: Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues. DISEASE: Salla disease Infantile sialic acid storage disorder Infantile sialic acid storage disorder is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders. Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. Database links: Entrez Gene: 26503 Human Entrez Gene: 235504 Mouse Entrez Gene: 363103 Rat Omim: 604322 Human SwissProt: Q9NRA2 Human SwissProt: Q8BN82 Mouse Unigene: 597422 Human Unigene: 46932 Mouse Unigene: 74591 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
这个基因编码一个膜转运体，它输出游离的唾液酸，这些唾液酸已经从细胞表面的脂质和溶酶体中被切割出来。该基因的突变导致唾液酸贮存疾病，包括婴儿唾液酸贮存障碍和萨尔拉病，形式。[ RefSeq，JUL 2008 ]